PAF-Mediated MAPK Signaling Hyperactivation via LAMTOR3 Induces Pancreatic Tumorigenesis

PAF-Mediated MAPK Signaling Hyperactivation via LAMTOR3 Induces Pancreatic Tumorigenesis

Deregulation of mitogen-activated protein kinase (MAPK) signaling leads to development of pancreatic cancer. Although Ras-mutation-driven pancreatic tumorigenesis is well understood, the underlying mechanism of Ras-independent MAPK hyperactivation remains elusive. Here, we have identified a distinct...

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Bibliographic Details
Main Authors: Sohee Jun, Sunhye Lee, Han-Cheon Kim, Christopher Ng, Andrea M. Schneider, Hong Ji, Haoqiang Ying, Huamin Wang, Ronald A. DePinho, Jae-Il Park
Format: Article
Language:English
Published: Elsevier 2013-10-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713005494

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http://www.sciencedirect.com/science/article/pii/S2211124713005494

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