Cav2.3 (R-Type) Calcium Channels are Critical for Mediating Anticonvulsive and Neuroprotective Properties of Lamotrigine In Vivo

Cav2.3 (R-Type) Calcium Channels are Critical for Mediating Anticonvulsive and Neuroprotective Properties of Lamotrigine In Vivo

Background/Aims: Lamotrigine (LTG) is a popular modern antiepileptic drug (AED), however, its mechanism of action has yet to be fully understood, as it is known to modulate many members of several ion channel families. In heterologous systems, LTG inhibits Cav2.3 (R-type) calcium currents, which con...

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Bibliographic Details
Main Authors: Maxine Dibué-Adjei, Marcel A. Kamp, Serdar Alpdogan, Etienne E. Tevoufouet, Wolfram F. Neiss, Jürgen Hescheler, Toni Schneider
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Lamotrigine
R-type
Cav2.3
Antiepileptic drugs
Toxicity
Quantitative electroencephalography
Online Access:https://www.karger.com/Article/FullText/485361

Internet

https://www.karger.com/Article/FullText/485361

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