Overexpression of enhancer of zeste homolog 2 with trimethylation of lysine 27 on histone H3 in adult T-cell leukemia/lymphoma as a target for epigenetic therapy

Overexpression of enhancer of zeste homolog 2 with trimethylation of lysine 27 on histone H3 in adult T-cell leukemia/lymphoma as a target for epigenetic therapy

Background Enhancer of zeste homolog 2 is a component of the Polycomb repressive complex 2 that mediates chromatin-based gene silencing through trimethylation of lysine 27 on histone H3. This complex plays vital roles in the regulation of development-specific gene expression.Design and Methods In th...

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Bibliographic Details
Main Authors: Daisuke Sasaki, Yoshitaka Imaizumi, Hiroo Hasegawa, Akemi Osaka, Kunihiro Tsukasaki, Young Lim Choi, Hiroyuki Mano, Victor E. Marquez, Tomayoshi Hayashi, Katsunori Yanagihara, Yuji Moriwaki, Yasushi Miyazaki, Shimeru Kamihira, Yasuaki Yamada
Format: Article
Language:English
Published: Ferrata Storti Foundation 2011-05-01
Series:Haematologica
Online Access:https://haematologica.org/article/view/5967

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https://haematologica.org/article/view/5967

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