Statistical methods for testing X chromosome variant associations: application to sex-specific characteristics of bipolar disorder

Statistical methods for testing X chromosome variant associations: application to sex-specific characteristics of bipolar disorder

Abstract Background Bipolar disorder (BD) affects both sexes, but important sex differences exist with respect to its symptoms and comorbidities. For example, rapid cycling (RC) is more prevalent in females, and alcohol use disorder (AUD) is more prevalent in males. We hypothesize that X chromosome...

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Bibliographic Details
Main Authors: William A. Jons, Colin L. Colby, Susan L. McElroy, Mark A. Frye, Joanna M. Biernacka, Stacey J. Winham
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Biology of Sex Differences
Subjects:
Bipolar disorder
X chromosome
Genetic association
Rapid cycling
Binge eating
Alcohol use disorder
Online Access:https://doi.org/10.1186/s13293-019-0272-4

Internet

https://doi.org/10.1186/s13293-019-0272-4

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