Tissue lipidomic profiling supports a mechanistic role of the prostaglandin E2 pathway for albuminuria development in glomerular hyperfiltration

Tissue lipidomic profiling supports a mechanistic role of the prostaglandin E2 pathway for albuminuria development in glomerular hyperfiltration

Background: Glomerular hyperfiltration (GH) is an important mechanism in the development of albuminuria in hypertension. The Munich Wistar Frömter (MWF) rat is a non-diabetic model of chronic kidney disease (CKD) with GH due to inherited low nephron number resulting in spontaneous albuminuria and po...

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Bibliographic Details
Main Authors: Debora Kaiser-Graf, Angela Schulz, Eva Mangelsen, Michael Rothe, Juliane Bolbrinker, Reinhold Kreutz
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Network Physiology
Subjects:
albuminuria
glomerular filtration
glomerular hyperfiltration
chronic kidney disease
lipidomic profiling
prostaglandin E2 pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fnetp.2023.1271042/full

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https://www.frontiersin.org/articles/10.3389/fnetp.2023.1271042/full

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