Isolation and Characterization of a Monobody with a Fibronectin Domain III Scaffold That Specifically Binds EphA2.

Isolation and Characterization of a Monobody with a Fibronectin Domain III Scaffold That Specifically Binds EphA2.

Monobodies are binding scaffold proteins originating from a human fibronectin domain III (Fn3) scaffold that can be easily engineered with specificity and affinity. Human EphA2 (hEphA2) is an early detection marker protein for various tumors including lung, breast, and colon cancer. In this study, w...

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Bibliographic Details
Main Authors: Seung-Hwan Park, Sukho Park, Dong-Yeon Kim, Ayoung Pyo, Richard H Kimura, Ataya Sathirachinda, Hyon E Choy, Jung-Joon Min, Sanjiv Sam Gambhir, Yeongjin Hong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4503726?pdf=render

Internet

http://europepmc.org/articles/PMC4503726?pdf=render

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