Endothelial Robo4 suppresses endothelial-to-mesenchymal transition induced by irradiation and improves hematopoietic reconstitution

Endothelial Robo4 suppresses endothelial-to-mesenchymal transition induced by irradiation and improves hematopoietic reconstitution

Abstract Bone marrow ablation is routinely performed before hematopoietic stem cell transplantation (HSCT). Hematopoietic stem and progenitor cells (HSPCs) require a stable bone marrow microenvironment to expand and refill the peripheral blood cell pool after ablation. Roundabout guidance receptor 4...

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Bibliographic Details
Main Authors: Seyram Yao Adzraku, Can Cao, Qi Zhou, Ke Yuan, Xiaowen Hao, Yue Li, Shengnan Yuan, Yujin Huang, Kailin Xu, Jianlin Qiao, Wen Ju, Lingyu Zeng
Format: Article
Language:English
Published: Nature Publishing Group 2024-02-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-06546-4

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https://doi.org/10.1038/s41419-024-06546-4

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