Simultaneous inhibition of FAK and ROS1 synergistically repressed triple-negative breast cancer by upregulating p53 signalling

Simultaneous inhibition of FAK and ROS1 synergistically repressed triple-negative breast cancer by upregulating p53 signalling

Abstract Background Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype lacking effective targeted therapies, necessitating innovative treatment approaches. While targeting ROS proto-oncogene 1 (ROS1) with crizotinib has shown promise, resistance remains a limitation. Recent...

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Bibliographic Details
Main Authors: Ximin Tan, Deguang Kong, Zhuoli Tao, Fangling Cheng, Baoyuan Zhang, Zaiqi Wang, Qi Mei, Chuang Chen, Kongming Wu
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Biomarker Research
Subjects:
FAK
ROS1
TNBC
Ferroptosis
Combination therapy
Organoid
Online Access:https://doi.org/10.1186/s40364-024-00558-0

Internet

https://doi.org/10.1186/s40364-024-00558-0

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