Increased intestinal permeability and downregulation of absorptive ion transporters Nhe3, Dra, and Sglt1 contribute to diarrhea during Clostridioides difficile infection

Increased intestinal permeability and downregulation of absorptive ion transporters Nhe3, Dra, and Sglt1 contribute to diarrhea during Clostridioides difficile infection

ABSTRACTBackground & Aim Clostridioides difficile infection (CDI) is the leading cause of hospital-acquired diarrhea and pseudomembranous colitis. Two protein toxins, TcdA and TcdB, produced by C. difficile are the major determinants of disease. However, the pathophysiological causes of diarrhea...

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Bibliographic Details
Main Authors: F. Christopher Peritore-Galve, Izumi Kaji, Anna Smith, Lauren M. Walker, John A. Shupe, M. Kay Washington, Holly M. Scott Algood, Pradeep K. Dudeja, James R. Goldenring, D. Borden Lacy
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Gut Microbes
Subjects:
Clostridioides difficile infection
paracellular permeability
ion transport
toxins
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2023.2225841

Internet

https://www.tandfonline.com/doi/10.1080/19490976.2023.2225841

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