Poloxamer-188 Adjuvant Efficiently Maintains Adaptive Immunity of SARS-CoV-2 RBD Subunit Vaccination through Repressing p38MAPK Signaling

Poloxamer-188 (P188) is a nonionic triblock linear copolymer that can be used as a pharmaceutical excipient because of its amphiphilic nature. This study investigated whether P188 can act as an adjuvant to improve the immunogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rec...

Full description

Bibliographic Details
Main Authors: Chao-Hung Chen, Yu-Jen Lin, Li-Ting Cheng, Chien-Hung Lin, Guan-Ming Ke
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Vaccines
Subjects:
Online Access:https://www.mdpi.com/2076-393X/10/5/715