Rare variants in GPR3 in POI patients: a case series with review of literature

Rare variants in GPR3 in POI patients: a case series with review of literature

Abstract Background Premature ovarian insufficiency (POI) is a highly heterogeneous disease, and up to 25% of the cases can be explained by genetic causes. G protein-coupled receptor 3 (GPR3) plays an important role in oocyte arrest, and Gpr3-deficient mice exhibited POI-like phenotypes. Case presen...

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Bibliografske podrobnosti
Main Authors: Shuting Ren, Feng Zhang, Lingyue Shang, Xi Yang, Yuncheng Pan, Xiaojin Zhang, Yanhua Wu
Format: Article
Jezik:English
Izdano: BMC 2023-11-01
Serija:Journal of Ovarian Research
Teme:
Premature ovarian insufficiency (POI)
G protein-coupled receptor 3 (GPR3)
Whole-exome sequencing (WES)
Single nucleotide variant (SNV)
Online dostop:https://doi.org/10.1186/s13048-023-01282-3

Internet

https://doi.org/10.1186/s13048-023-01282-3

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