Ion occupancy of the selectivity filter controls opening of a cytoplasmic gate in the K2P channel TALK-2

Ion occupancy of the selectivity filter controls opening of a cytoplasmic gate in the K2P channel TALK-2

Abstract Two-pore domain K+ (K2P) channel activity was previously thought to be controlled primarily via a selectivity filter (SF) gate. However, recent crystal structures of TASK-1 and TASK-2 revealed a lower gate at the cytoplasmic pore entrance. Here, we report functional evidence of such a lower...

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Bibliografische gegevens
Hoofdauteurs: Lea C. Neelsen, Elena B. Riel, Susanne Rinné, Freya-Rebecca Schmid, Björn C. Jürs, Mauricio Bedoya, Jan P. Langer, Bisher Eymsh, Aytug K. Kiper, Sönke Cordeiro, Niels Decher, Thomas Baukrowitz, Marcus Schewe
Formaat: Artikel
Taal:English
Gepubliceerd in: Nature Portfolio 2024-08-01
Reeks:Nature Communications
Online toegang:https://doi.org/10.1038/s41467-024-51812-w

Internet

https://doi.org/10.1038/s41467-024-51812-w

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