Sos1 deficiency ameliorates oncogenic KRAS-mediated hematopoietic stem cell exhaustion and myeloid progenitor expansion

Sos1 deficiency ameliorates oncogenic KRAS-mediated hematopoietic stem cell exhaustion and myeloid progenitor expansion

Constitutive KRAS activating mutations are prevalent in hematopoietic malignancies. Our previous study showed that the deficiency of Sos1 prolongs the survival of KrasG12D/+ mice. However, whether Sos1 deletion ameliorates oncogenic Kras-mediated hematopoietic defects remains unknown. Here, we found...

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Bibliographic Details
Main Authors: Maoshuo Yang, Lanlan Liu, Yaqing Miao, Yongxin Jia, Sijia Tian, Limei Wang, Fabao Liu, Xiaona You
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Pharmaceutical Science Advances
Subjects:
Sos1
Kras
Hematopoietic stem cell
Quiescent
ERK signaling
Online Access:http://www.sciencedirect.com/science/article/pii/S2773216924000199

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http://www.sciencedirect.com/science/article/pii/S2773216924000199

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