The Annexin-A1 mimetic RTP-026 promotes acute cardioprotection through modulation of immune cell activation

The Annexin-A1 mimetic RTP-026 promotes acute cardioprotection through modulation of immune cell activation

Aims: The cardio-protective and immuno-regulatory properties of RTP-026, a synthetic peptide that spans the Annexin-A1 (AnxA1) N-terminal region, were tested in rat acute myocardial infarction. Methods and results: In vitro, selective activation of formyl-peptide receptor type 2 (FPR2) by RTP-026 oc...

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Bibliographic Details
Main Authors: Jianmin Chen, Silvia Oggero, Chiara Cecconello, Jesmond Dalli, Hedayatullah Hayat, Ahmad Hjiej Andaloussi, Samra Sanni, Thomas EN Jonassen, Mauro Perretti
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Pharmacological Research
Subjects:
Annexin-A1
Heart
Myocardial ischemia/reperfusion
Resolution of inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661823003614

Internet

http://www.sciencedirect.com/science/article/pii/S1043661823003614

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