Pomegranate peel extract protects against the development of diabetic cardiomyopathy in rats by inhibiting pyroptosis and downregulating LncRNA-MALAT1

Pomegranate peel extract protects against the development of diabetic cardiomyopathy in rats by inhibiting pyroptosis and downregulating LncRNA-MALAT1

Background: Pyroptosis is an inflammatory programmed cell death accompanied by activation of inflammasomes and maturation of pro-inflammatory cytokines interleukin-1β (IL-1β) and IL-18. Pyroptosis is closely linked to the development of diabetic cardiomyopathy (DC). Pomegranate peel extract (PPE) ex...

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Bibliographic Details
Main Authors: Mariam Ali Abo-Saif, Amany E. Ragab, Amera O. Ibrahim, Othman F. Abdelzaher, Ahmed B. M. Mehanyd, Maha Saber-Ayad, Ola A. El-Feky
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Pharmacology
Subjects:
long non-coding RNA-metastasis-associated lung adenocarcinoma transcript-1
NLRP3
caspase-1
IL1β
TGF-β
pomegranate peel extract
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1166653/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1166653/full

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