Gaussian curvature dilutes the nuclear lamina, favoring nuclear rupture, especially at high strain rate

Gaussian curvature dilutes the nuclear lamina, favoring nuclear rupture, especially at high strain rate

Nuclear rupture has long been associated with deficits or defects in lamins, with recent results also indicating a role for actomyosin stress, but key physical determinants of rupture remain unclear. Here, lamin-B filaments stably interact with the nuclear membrane at sites of low Gaussian curvature...

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Bibliographic Details
Main Authors: Charlotte R. Pfeifer, Michael P. Tobin, Sangkyun Cho, Manasvita Vashisth, Lawrence J. Dooling, Lizeth Lopez Vazquez, Emma G. Ricci-De Lucca, Keiann T. Simon, Dennis E. Discher
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Nucleus
Subjects:
curvature
nuclear lamina
nuclear envelope rupture
myosin stress
biophysical model
mechanobiology
Online Access:https://www.tandfonline.com/doi/10.1080/19491034.2022.2045726

Internet

https://www.tandfonline.com/doi/10.1080/19491034.2022.2045726

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