Structural Analysis of SMYD3 Lysine Methyltransferase for the Development of Competitive and Specific Enzyme Inhibitors

Structural Analysis of SMYD3 Lysine Methyltransferase for the Development of Competitive and Specific Enzyme Inhibitors

Lysine methylation is among the key posttranslational modifications to histones that contribute to epigenetic regulation. SMYD3 is a lysine methyltransferase that is essential for the proliferation of a range of tumorigenic cells. The findings that SMYD3 is significantly upregulated in most colorect...

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Bibliographic Details
Main Authors: Dillon K. Jarrell, Kelly N. Hassell, Ilham Alshiraihi, Debbie C. Crans, Mark A. Brown
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Diseases
Subjects:
SET-domain proteins
histones
Rubisco-LSMT
small molecule enzyme inhibitors
colorectal
lung carcinoma
Online Access:https://www.mdpi.com/2079-9721/10/1/4

Internet

https://www.mdpi.com/2079-9721/10/1/4

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