The potential of the antifungal nystatin to be repurposed to fight the protozoan Trypanosoma cruzi

The potential of the antifungal nystatin to be repurposed to fight the protozoan Trypanosoma cruzi

Chagas disease, caused by the parasite Trypanosoma cruzi, affects 6 million people worldwide. Although the drugs benznidazole (BZN) and nifurtimox are available to treat Chagas, they are not effective in the chronic phase when most patients are diagnosed. Moreover, long-term regimen and severe side...

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Bibliographic Details
Main Authors: Belén Jesús Maciel, Chantal Reigada, Fabio Augusto Digirolamo, Marcos Rengifo, Claudio Alejandro Pereira, Mariana Reneé Miranda, Melisa Sayé
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Microbiology
Subjects:
nystatin
drug repurposing
Trypanosoma cruzi
trypanocidal compounds
Chagas disease
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1539629/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2025.1539629/full

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