Single-cell analyses reveal the therapeutic effects of ATHENA and its mechanism in a rhabdomyosarcoma patient

Single-cell analyses reveal the therapeutic effects of ATHENA and its mechanism in a rhabdomyosarcoma patient

BackgroundWhole-cell tumor vaccines tend to suffer from low immunogenicity. Our previous study showed that irradiated lung cancer cell vaccines in mouse models enhance antitumor efficacy by eliciting an intensive T cells response and improving immunogenicity. Based on these findings, we developed an...

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Bibliographic Details
Main Authors: Yujun Liu, Ke Wang, Yanli Zhou, Xibing Zhuang, Shali Shao, Fulu Qiao, Xiangdong Wang, Xin Zou, Tiankui Qiao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Oncology
Subjects:
single-cell RNA sequencing
autologous tumor vaccines
scSTAR
T cells
B cells
exhausted state
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1039145/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.1039145/full

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