Cholesterol restricts lymphotoxin β receptor-triggered NF-κB signaling

Cholesterol restricts lymphotoxin β receptor-triggered NF-κB signaling

Abstract Background Lymphotoxin β receptor (LTβR) plays important roles in the development of the immune system and immune response. At the cellular level, ligand-bound LTβR activates the pro-inflammatory NF-κB pathway but the detailed mechanisms regulating its signaling remain unknown. Understandin...

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Bibliographic Details
Main Authors: Magdalena Banach-Orłowska, Renata Wyszyńska, Beata Pyrzyńska, Małgorzata Maksymowicz, Jakub Gołąb, Marta Miączyńska
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Cell Communication and Signaling
Subjects:
Lymphotoxin β receptor
Cholesterol
NF-κB signaling
NEMO
TRAF2
Receptor internalization
Online Access:https://doi.org/10.1186/s12964-019-0460-1

Internet

https://doi.org/10.1186/s12964-019-0460-1

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