EGFR/ErbB Inhibition Promotes OPC Maturation up to Axon Engagement by Co-Regulating PIP2 and MBP

EGFR/ErbB Inhibition Promotes OPC Maturation up to Axon Engagement by Co-Regulating PIP2 and MBP

Remyelination in the adult brain relies on the reactivation of the Neuronal Precursor Cell (NPC) niche and differentiation into Oligodendrocyte Precursor Cells (OPCs) as well as on OPC maturation into myelinating oligodendrocytes (OLs). These two distinct phases in OL development are defined by tran...

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Bibliographic Details
Main Authors: Emanuela Nocita, Alice Del Giovane, Marta Tiberi, Laura Boccuni, Denise Fiorelli, Carola Sposato, Elena Romano, Francesco Basoli, Marcella Trombetta, Alberto Rainer, Enrico Traversa, Antonella Ragnini-Wilson
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cells
Subjects:
remyelination
EGFR inhibitor
smoothened agonist
microfibers
drug screening
Online Access:https://www.mdpi.com/2073-4409/8/8/844

Internet

https://www.mdpi.com/2073-4409/8/8/844

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