Unnatural amino acid substitutions to improve in vivo stability and tumor uptake of 68Ga-labeled GRPR-targeted TacBOMB2 derivatives for cancer imaging with positron emission tomography

Unnatural amino acid substitutions to improve in vivo stability and tumor uptake of 68Ga-labeled GRPR-targeted TacBOMB2 derivatives for cancer imaging with positron emission tomography

Abstract Background Overexpressed in various solid tumors, gastrin-releasing peptide receptor (GRPR) is a promising cancer imaging marker and therapeutic target. Although antagonists are preferable for the development of GRPR-targeted radiopharmaceuticals due to potentially fewer side effects, inter...

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Bibliographic Details
Main Authors: Lei Wang, Hsiou-Ting Kuo, Zhengxing Zhang, Chengcheng Zhang, Chao-Cheng Chen, Devon Chapple, Ryan Wilson, Nadine Colpo, François Bénard, Kuo-Shyan Lin
Format: Article
Language:English
Published: SpringerOpen 2024-02-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
Gastrin-releasing peptide receptor
Agonist
In vivo stability
Positron emission tomography
Pancreas uptake
Online Access:https://doi.org/10.1186/s41181-024-00241-7

Internet

https://doi.org/10.1186/s41181-024-00241-7

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