Structural and Conformational Studies on Carboxamides of 5,6-Diaminouracils—Precursors of Biologically Active Xanthine Derivatives

Structural and Conformational Studies on Carboxamides of 5,6-Diaminouracils—Precursors of Biologically Active Xanthine Derivatives

8-Arylethynylxanthine derivatives are potent, selective adenosine A<sub>2A</sub> receptor antagonists, which represent (potential) therapeutics for Parkinson&#8217;s disease, Alzheimer&#8217;s dementia, and the immunotherapy of cancer. 6-Amino-5-amidouracil derivatives are import...

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Bibliographic Details
Main Authors: Daniel Marx, Gregor Schnakenburg, Stefan Grimme, Christa E. Müller
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Molecules
Subjects:
amide
DFT calculation
dynamic NMR
rotamers/conformers
uracil
xanthine
X-ray crystallography
Online Access:https://www.mdpi.com/1420-3049/24/11/2168

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https://www.mdpi.com/1420-3049/24/11/2168

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