Simultaneous Inhibition of Histone Deacetylases and RNA Synthesis Enables Totipotency Reprogramming in Pig SCNT Embryos

Simultaneous Inhibition of Histone Deacetylases and RNA Synthesis Enables Totipotency Reprogramming in Pig SCNT Embryos

Combining somatic cell nuclear transfer (SCNT) with genome editing technologies has emerged as a powerful platform for the creation of unique swine lineages for agricultural and biomedical applications. However, successful application of this research platform is still hampered by the low efficiency...

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Bibliographic Details
Main Authors: Mariana Priotto de Macedo, Werner Giehl Glanzner, Karina Gutierrez, Luke Currin, Vanessa Guay, Maria Elena Carrillo Herrera, Zigomar da Silva, Hernan Baldassarre, Serge McGraw, Vilceu Bordignon
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
SCNT
cell reprogramming
HDACi
DRB
porcine
Online Access:https://www.mdpi.com/1422-0067/23/22/14142

Internet

https://www.mdpi.com/1422-0067/23/22/14142

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