Evaluation of the effect of carnosine, its novel derivative trolox-carnosine and trolox in a pre-clinical study focussing on the regulation of immunity
The neuroprotective or neurotoxic effects of the products of the kynurenine pathway of tryptophan metabolism highly depend on the action of kynurenine-3-monooxygenase (KMO). The present results show increased concentrations of the KMO in the plasma of rats repeatedly exposed to an immune challenge....
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2016-09-01
|
| Series: | European Pharmaceutical Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/afpuc-2016-0001 |
| _version_ | 1819007298940436480 |
|---|---|
| author | Slovák L. Poništ S. Kuncírová V. Mihalová D. Fedorova T. Bauerová K. |
| author_facet | Slovák L. Poništ S. Kuncírová V. Mihalová D. Fedorova T. Bauerová K. |
| author_sort | Slovák L. |
| collection | DOAJ |
| description | The neuroprotective or neurotoxic effects of the products of the kynurenine pathway of tryptophan metabolism highly depend on the action of kynurenine-3-monooxygenase (KMO). The present results show increased concentrations of the KMO in the plasma of rats repeatedly exposed to an immune challenge. Increased concentrations of this key enzyme are likely to cause a shift of kynurenine pathway towards enhanced production of neurotoxic metabolites. |
| first_indexed | 2024-12-21T00:22:22Z |
| format | Article |
| id | doaj.art-250657bdbea4402390be20cda1425e3b |
| institution | Directory Open Access Journal |
| issn | 2453-6725 |
| language | English |
| last_indexed | 2024-12-21T00:22:22Z |
| publishDate | 2016-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | European Pharmaceutical Journal |
| spelling | doaj.art-250657bdbea4402390be20cda1425e3b2022-12-21T19:22:04ZengSciendoEuropean Pharmaceutical Journal2453-67252016-09-01631161910.1515/afpuc-2016-0001afpuc-2016-0001Evaluation of the effect of carnosine, its novel derivative trolox-carnosine and trolox in a pre-clinical study focussing on the regulation of immunitySlovák L.0Poništ S.1Kuncírová V.2Mihalová D.3Fedorova T.4Bauerová K.5Slovak Academy of Sciences, Institute of Experimental Pharmacology and Toxicology, Bratislava SlovakiaSlovak Academy of Sciences, Institute of Experimental Pharmacology and Toxicology, Bratislava,SlovakiaSlovak Academy of Sciences, Institute of Experimental Pharmacology and Toxicology, Bratislava,SlovakiaSlovak Academy of Sciences, Institute of Experimental Pharmacology and Toxicology, Bratislava,SlovakiaResearch Center of Neurology, Moscow, Russian FederationSlovak Academy of Sciences, Institute of Experimental Pharmacology and Toxicology, Bratislava SlovakiaThe neuroprotective or neurotoxic effects of the products of the kynurenine pathway of tryptophan metabolism highly depend on the action of kynurenine-3-monooxygenase (KMO). The present results show increased concentrations of the KMO in the plasma of rats repeatedly exposed to an immune challenge. Increased concentrations of this key enzyme are likely to cause a shift of kynurenine pathway towards enhanced production of neurotoxic metabolites.https://doi.org/10.1515/afpuc-2016-0001immune challengekynurenine-3-monooxygenasegender |
| spellingShingle | Slovák L. Poništ S. Kuncírová V. Mihalová D. Fedorova T. Bauerová K. Evaluation of the effect of carnosine, its novel derivative trolox-carnosine and trolox in a pre-clinical study focussing on the regulation of immunity European Pharmaceutical Journal immune challenge kynurenine-3-monooxygenase gender |
| title | Evaluation of the effect of carnosine, its novel derivative trolox-carnosine and trolox in a pre-clinical study focussing on the regulation of immunity |
| title_full | Evaluation of the effect of carnosine, its novel derivative trolox-carnosine and trolox in a pre-clinical study focussing on the regulation of immunity |
| title_fullStr | Evaluation of the effect of carnosine, its novel derivative trolox-carnosine and trolox in a pre-clinical study focussing on the regulation of immunity |
| title_full_unstemmed | Evaluation of the effect of carnosine, its novel derivative trolox-carnosine and trolox in a pre-clinical study focussing on the regulation of immunity |
| title_short | Evaluation of the effect of carnosine, its novel derivative trolox-carnosine and trolox in a pre-clinical study focussing on the regulation of immunity |
| title_sort | evaluation of the effect of carnosine its novel derivative trolox carnosine and trolox in a pre clinical study focussing on the regulation of immunity |
| topic | immune challenge kynurenine-3-monooxygenase gender |
| url | https://doi.org/10.1515/afpuc-2016-0001 |
| work_keys_str_mv | AT slovakl evaluationoftheeffectofcarnosineitsnovelderivativetroloxcarnosineandtroloxinapreclinicalstudyfocussingontheregulationofimmunity AT ponists evaluationoftheeffectofcarnosineitsnovelderivativetroloxcarnosineandtroloxinapreclinicalstudyfocussingontheregulationofimmunity AT kuncirovav evaluationoftheeffectofcarnosineitsnovelderivativetroloxcarnosineandtroloxinapreclinicalstudyfocussingontheregulationofimmunity AT mihalovad evaluationoftheeffectofcarnosineitsnovelderivativetroloxcarnosineandtroloxinapreclinicalstudyfocussingontheregulationofimmunity AT fedorovat evaluationoftheeffectofcarnosineitsnovelderivativetroloxcarnosineandtroloxinapreclinicalstudyfocussingontheregulationofimmunity AT bauerovak evaluationoftheeffectofcarnosineitsnovelderivativetroloxcarnosineandtroloxinapreclinicalstudyfocussingontheregulationofimmunity |