GSK2606414 attenuates PERK/p-eIF2α/ATF4/CHOP axis and augments mitochondrial function to mitigate high glucose induced neurotoxicity in N2A cells

GSK2606414 attenuates PERK/p-eIF2α/ATF4/CHOP axis and augments mitochondrial function to mitigate high glucose induced neurotoxicity in N2A cells

Neuronal dysfunction and subsequent apoptosis under high glucose conditions during diabetes contribute majorly to the manifestation of diabetic peripheral neuropathy (DPN). PERK (protein kinase RNA (PKR)-like ER kinase) one among the three canonical arms of unfolded protein response (UPR), is believ...

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Bibliographic Details
Main Authors: Chayanika Gundu, Vijay Kumar Arruri, Bhoomika Sherkhane, Dharmendra Kumar Khatri, Shashi Bala Singh
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Current Research in Pharmacology and Drug Discovery
Subjects:
GSK2606414
High glucose
PERK
ER stress
Mitochondrial function
Online Access:http://www.sciencedirect.com/science/article/pii/S2590257122000074

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http://www.sciencedirect.com/science/article/pii/S2590257122000074

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