Unbiased screen for pathogens in human paraffin-embedded tissue samples by whole genome sequencing and metagenomics

Unbiased screen for pathogens in human paraffin-embedded tissue samples by whole genome sequencing and metagenomics

Identification of bacterial pathogens in formalin fixed, paraffin embedded (FFPE) tissue samples is limited to targeted and resource-intensive methods such as sequential PCR analyses. To enable unbiased screening for pathogens in FFPE tissue samples, we established a whole genome sequencing (WGS) me...

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Bibliographic Details
Main Authors: Ronny Nienhold, Nadine Mensah, Angela Frank, Anne Graber, Jacqueline Koike, Nathalie Schwab, Claudia Hernach, Veronika Zsikla, Niels Willi, Gieri Cathomas, Baptiste Hamelin, Susanne Graf, Tobias Junt, Kirsten D. Mertz
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
pathology
infection
pathogen identification
metagenomics
next-generation sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2022.968135/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2022.968135/full

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