MOGAD patient autoantibodies induce complement, phagocytosis, and cellular cytotoxicity

MOGAD patient autoantibodies induce complement, phagocytosis, and cellular cytotoxicity

Myelin oligodendrocyte glycoprotein (MOG) antibody–associated disease (MOGAD) is an inflammatory demyelinating CNS condition characterized by the presence of MOG autoantibodies. We sought to investigate whether human MOG autoantibodies are capable of mediating damage to MOG-expressing cells through...

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Bibliographic Details
Main Authors: Soumya S. Yandamuri, Beata Filipek, Abeer H. Obaid, Nikhil Lele, Joshua M. Thurman, Naila Makhani, Richard J. Nowak, Yong Guo, Claudia F. Lucchinetti, Eoin P. Flanagan, Erin E. Longbrake, Kevin C. O’Connor
Format: Article
Language:English
Published: American Society for Clinical investigation 2023-06-01
Series:JCI Insight
Subjects:
Autoimmunity
Neuroscience
Online Access:https://doi.org/10.1172/jci.insight.165373

Internet

https://doi.org/10.1172/jci.insight.165373

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