Skeletal muscle cystathionine γ-lyase deficiency promotes obesity and insulin resistance and results in hyperglycemia and skeletal muscle injury upon HFD in mice

Skeletal muscle cystathionine γ-lyase deficiency promotes obesity and insulin resistance and results in hyperglycemia and skeletal muscle injury upon HFD in mice

Objectives The objective of this study was to investigate whether skeletal muscle cystathionine γ-lyase (CTH) contributes to high-fat diet (HFD)-induced metabolic disorders using skeletal muscle Cth knockout (CthΔskm) mice.Methods The CthΔskm mice and littermate Cth-floxed (Cthf/f) mice were fed wit...

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Bibliographic Details
Main Authors: Jiani Lu, Zhengshan Tang, Miaomiao Xu, Jianqiang Lu, Fengmei Wang, Xin Ni, Changnan Wang, Bo Yu
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Redox Report
Subjects:
Cystathionine γ-lyase
insulin resistance
skeletal muscle
high-fat diet
oxidative stress
ferroptosis
Online Access:https://www.tandfonline.com/doi/10.1080/13510002.2024.2347139

Internet

https://www.tandfonline.com/doi/10.1080/13510002.2024.2347139

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