Circular RNA circ-4099 is induced by TNF-α and regulates ECM synthesis by blocking miR-616-5p inhibition of Sox9 in intervertebral disc degeneration

Circular RNA circ-4099 is induced by TNF-α and regulates ECM synthesis by blocking miR-616-5p inhibition of Sox9 in intervertebral disc degeneration

Spinal disease: Circular RNA linked to disc degeneration A circular RNA molecule helps protect against degenerative disc disease. Hua Wang and coworkers from Sun Yat-Sen University in Guangzhou, China, examined whether circular RNAs, regulatory molecules that take the form of closed RNA loops, contr...

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Bibliographic Details
Main Authors: Hua Wang, Peiheng He, Hehai Pan, Jun long, Jianru Wang, Zemin Li, Hui Liu, Weiying Jiang, Zhaomin Zheng
Format: Article
Language:English
Published: Nature Publishing Group 2018-04-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-018-0056-7

Internet

https://doi.org/10.1038/s12276-018-0056-7

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