A novel multimeric sCD19‐streptavidin fusion protein for functional detection and selective expansion of CD19‐targeted CAR‐T cells

A novel multimeric sCD19‐streptavidin fusion protein for functional detection and selective expansion of CD19‐targeted CAR‐T cells

Abstract Background CARs are engineered receptors comprising an immunoglobulin single‐chain variable fragment (scFv) that identifies and binds to the target antigen, a transmembrane domain, and an intracellular T‐cell signaling domain. CD19 is a B lineage‐specific transmembrane glycoprotein and is e...

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Bibliographic Details
Main Authors: Hui Lian, Jinhong Jiang, Yao Wang, Xiaoxiao Yu, Rong Zheng, Jing Long, Mengjie Zhou, Shirong Zhou, Cheng Wei, Ai Zhao, Jimin Gao
Format: Article
Language:English
Published: Wiley 2022-08-01
Series:Cancer Medicine
Subjects:
CAR‐T cells
CD19
fusion protein
streptavidin
Online Access:https://doi.org/10.1002/cam4.4657

Internet

https://doi.org/10.1002/cam4.4657

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