Genome-wide genotype-serum proteome mapping provides insights into the cross-ancestry differences in cardiometabolic disease susceptibility
Integrating genetic information with circulating proteomics can help understand mechanisms of disease. Here, the authors conduct genome-wide association analyses of the serum proteome in 2,958 Han Chinese individuals, uncovering proteins which may contribute to ancestry differences in cardiometaboli...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-36491-3 |
| _version_ | 1827983404643123200 |
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| author | Fengzhe Xu Evan Yi-Wen Yu Xue Cai Liang Yue Li-peng Jing Xinxiu Liang Yuanqing Fu Zelei Miao Min Yang Menglei Shuai Wanglong Gou Congmei Xiao Zhangzhi Xue Yuting Xie Sainan Li Sha Lu Meiqi Shi Xuhong Wang Wensheng Hu Claudia Langenberg Jian Yang Yu-ming Chen Tiannan Guo Ju-Sheng Zheng |
| author_facet | Fengzhe Xu Evan Yi-Wen Yu Xue Cai Liang Yue Li-peng Jing Xinxiu Liang Yuanqing Fu Zelei Miao Min Yang Menglei Shuai Wanglong Gou Congmei Xiao Zhangzhi Xue Yuting Xie Sainan Li Sha Lu Meiqi Shi Xuhong Wang Wensheng Hu Claudia Langenberg Jian Yang Yu-ming Chen Tiannan Guo Ju-Sheng Zheng |
| author_sort | Fengzhe Xu |
| collection | DOAJ |
| description | Integrating genetic information with circulating proteomics can help understand mechanisms of disease. Here, the authors conduct genome-wide association analyses of the serum proteome in 2,958 Han Chinese individuals, uncovering proteins which may contribute to ancestry differences in cardiometabolic disease susceptibility. |
| first_indexed | 2024-04-09T22:46:42Z |
| format | Article |
| id | doaj.art-251065f86fd649ae998a9091c8fc8b46 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T22:46:42Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-251065f86fd649ae998a9091c8fc8b462023-03-22T11:46:35ZengNature PortfolioNature Communications2041-17232023-02-0114111210.1038/s41467-023-36491-3Genome-wide genotype-serum proteome mapping provides insights into the cross-ancestry differences in cardiometabolic disease susceptibilityFengzhe Xu0Evan Yi-Wen Yu1Xue Cai2Liang Yue3Li-peng Jing4Xinxiu Liang5Yuanqing Fu6Zelei Miao7Min Yang8Menglei Shuai9Wanglong Gou10Congmei Xiao11Zhangzhi Xue12Yuting Xie13Sainan Li14Sha Lu15Meiqi Shi16Xuhong Wang17Wensheng Hu18Claudia Langenberg19Jian Yang20Yu-ming Chen21Tiannan Guo22Ju-Sheng Zheng23School of Life Sciences, Fudan UniversityKey Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Epidemiology & Biostatistics, School of Public Health, Southeast UniversitySchool of Life Sciences, Westlake UniversitySchool of Life Sciences, Westlake UniversityGuangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Epidemiology, School of Public Health, Sun Yat-sen UniversitySchool of Life Sciences, Westlake UniversitySchool of Life Sciences, Westlake UniversitySchool of Life Sciences, Westlake UniversitySchool of Life Sciences, Westlake UniversitySchool of Life Sciences, Westlake UniversitySchool of Life Sciences, Westlake UniversitySchool of Life Sciences, Westlake UniversitySchool of Life Sciences, Westlake UniversitySchool of Life Sciences, Westlake UniversitySchool of Life Sciences, Westlake UniversityHangzhou Women’s Hospital (Hangzhou Maternity and Child Health Care Hospital)Hangzhou Women’s Hospital (Hangzhou Maternity and Child Health Care Hospital)Hangzhou Women’s Hospital (Hangzhou Maternity and Child Health Care Hospital)Hangzhou Women’s Hospital (Hangzhou Maternity and Child Health Care Hospital)MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical MedicineSchool of Life Sciences, Westlake UniversityGuangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Epidemiology, School of Public Health, Sun Yat-sen UniversitySchool of Life Sciences, Westlake UniversitySchool of Life Sciences, Westlake UniversityIntegrating genetic information with circulating proteomics can help understand mechanisms of disease. Here, the authors conduct genome-wide association analyses of the serum proteome in 2,958 Han Chinese individuals, uncovering proteins which may contribute to ancestry differences in cardiometabolic disease susceptibility.https://doi.org/10.1038/s41467-023-36491-3 |
| spellingShingle | Fengzhe Xu Evan Yi-Wen Yu Xue Cai Liang Yue Li-peng Jing Xinxiu Liang Yuanqing Fu Zelei Miao Min Yang Menglei Shuai Wanglong Gou Congmei Xiao Zhangzhi Xue Yuting Xie Sainan Li Sha Lu Meiqi Shi Xuhong Wang Wensheng Hu Claudia Langenberg Jian Yang Yu-ming Chen Tiannan Guo Ju-Sheng Zheng Genome-wide genotype-serum proteome mapping provides insights into the cross-ancestry differences in cardiometabolic disease susceptibility Nature Communications |
| title | Genome-wide genotype-serum proteome mapping provides insights into the cross-ancestry differences in cardiometabolic disease susceptibility |
| title_full | Genome-wide genotype-serum proteome mapping provides insights into the cross-ancestry differences in cardiometabolic disease susceptibility |
| title_fullStr | Genome-wide genotype-serum proteome mapping provides insights into the cross-ancestry differences in cardiometabolic disease susceptibility |
| title_full_unstemmed | Genome-wide genotype-serum proteome mapping provides insights into the cross-ancestry differences in cardiometabolic disease susceptibility |
| title_short | Genome-wide genotype-serum proteome mapping provides insights into the cross-ancestry differences in cardiometabolic disease susceptibility |
| title_sort | genome wide genotype serum proteome mapping provides insights into the cross ancestry differences in cardiometabolic disease susceptibility |
| url | https://doi.org/10.1038/s41467-023-36491-3 |
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