Human CD22-Transgenic, Primary Murine Lymphoma Challenges Immunotherapies in Organ-Specific Tumor Microenvironments

Human CD22-Transgenic, Primary Murine Lymphoma Challenges Immunotherapies in Organ-Specific Tumor Microenvironments

Targeted immunotherapies have greatly changed treatment of patients with B cell malignancies. To further enhance immunotherapies, research increasingly focuses on the tumor microenvironment (TME), which differs considerably by organ site. However, immunocompetent mouse models of disease to study imm...

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Bibliographic Details
Main Authors: Franziska Gsottberger, Carolin Brandl, Kerstin Wendland, Srdjan Petkovic, Charlotte Emmerich, Ramona Erber, Carol Geppert, Arndt Hartmann, Andreas Mackensen, Lars Nitschke, Fabian Müller
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
<i>myc</i>-driven lymphoma
mouse model
lymphoma microenvironment
tumor microenvironment
CD22
immunotoxin
Online Access:https://www.mdpi.com/1422-0067/22/19/10433

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https://www.mdpi.com/1422-0067/22/19/10433

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