ERK-mediated NELF-A phosphorylation promotes transcription elongation of immediate-early genes by releasing promoter-proximal pausing of RNA polymerase II

ERK-mediated NELF-A phosphorylation promotes transcription elongation of immediate-early genes by releasing promoter-proximal pausing of RNA polymerase II

Growth factor-induced release of RNA Pol-II promoter-proximal pausing is vital for immediate-early gene expression, but its mechanism remains elusive. Here, the authors reveal roles of ERK and PP2A in this process and their dysregulation in cancer.

Bibliographic Details
Main Authors: Seina Ohe, Yuji Kubota, Kiyoshi Yamaguchi, Yusuke Takagi, Junichiro Nashimoto, Hiroko Kozuka-Hata, Masaaki Oyama, Yoichi Furukawa, Mutsuhiro Takekawa
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-35230-4

Internet

https://doi.org/10.1038/s41467-022-35230-4

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