ERK-mediated NELF-A phosphorylation promotes transcription elongation of immediate-early genes by releasing promoter-proximal pausing of RNA polymerase II
Growth factor-induced release of RNA Pol-II promoter-proximal pausing is vital for immediate-early gene expression, but its mechanism remains elusive. Here, the authors reveal roles of ERK and PP2A in this process and their dysregulation in cancer.
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-35230-4 |
| _version_ | 1811315022947680256 |
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| author | Seina Ohe Yuji Kubota Kiyoshi Yamaguchi Yusuke Takagi Junichiro Nashimoto Hiroko Kozuka-Hata Masaaki Oyama Yoichi Furukawa Mutsuhiro Takekawa |
| author_facet | Seina Ohe Yuji Kubota Kiyoshi Yamaguchi Yusuke Takagi Junichiro Nashimoto Hiroko Kozuka-Hata Masaaki Oyama Yoichi Furukawa Mutsuhiro Takekawa |
| author_sort | Seina Ohe |
| collection | DOAJ |
| description | Growth factor-induced release of RNA Pol-II promoter-proximal pausing is vital for immediate-early gene expression, but its mechanism remains elusive. Here, the authors reveal roles of ERK and PP2A in this process and their dysregulation in cancer. |
| first_indexed | 2024-04-13T11:22:48Z |
| format | Article |
| id | doaj.art-25151774c4324719bb372acd2dd5e18f |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T11:22:48Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-25151774c4324719bb372acd2dd5e18f2022-12-22T02:48:46ZengNature PortfolioNature Communications2041-17232022-12-0113111710.1038/s41467-022-35230-4ERK-mediated NELF-A phosphorylation promotes transcription elongation of immediate-early genes by releasing promoter-proximal pausing of RNA polymerase IISeina Ohe0Yuji Kubota1Kiyoshi Yamaguchi2Yusuke Takagi3Junichiro Nashimoto4Hiroko Kozuka-Hata5Masaaki Oyama6Yoichi Furukawa7Mutsuhiro Takekawa8Division of Cell Signaling and Molecular Medicine, Institute of Medical Science, The University of TokyoDivision of Cell Signaling and Molecular Medicine, Institute of Medical Science, The University of TokyoDivision of Clinical Genome Research, Institute of Medical Science, The University of TokyoDivision of Cell Signaling and Molecular Medicine, Institute of Medical Science, The University of TokyoDivision of Cell Signaling and Molecular Medicine, Institute of Medical Science, The University of TokyoMedical Proteomics Laboratory, Institute of Medical Science, The University of TokyoMedical Proteomics Laboratory, Institute of Medical Science, The University of TokyoDivision of Clinical Genome Research, Institute of Medical Science, The University of TokyoDivision of Cell Signaling and Molecular Medicine, Institute of Medical Science, The University of TokyoGrowth factor-induced release of RNA Pol-II promoter-proximal pausing is vital for immediate-early gene expression, but its mechanism remains elusive. Here, the authors reveal roles of ERK and PP2A in this process and their dysregulation in cancer.https://doi.org/10.1038/s41467-022-35230-4 |
| spellingShingle | Seina Ohe Yuji Kubota Kiyoshi Yamaguchi Yusuke Takagi Junichiro Nashimoto Hiroko Kozuka-Hata Masaaki Oyama Yoichi Furukawa Mutsuhiro Takekawa ERK-mediated NELF-A phosphorylation promotes transcription elongation of immediate-early genes by releasing promoter-proximal pausing of RNA polymerase II Nature Communications |
| title | ERK-mediated NELF-A phosphorylation promotes transcription elongation of immediate-early genes by releasing promoter-proximal pausing of RNA polymerase II |
| title_full | ERK-mediated NELF-A phosphorylation promotes transcription elongation of immediate-early genes by releasing promoter-proximal pausing of RNA polymerase II |
| title_fullStr | ERK-mediated NELF-A phosphorylation promotes transcription elongation of immediate-early genes by releasing promoter-proximal pausing of RNA polymerase II |
| title_full_unstemmed | ERK-mediated NELF-A phosphorylation promotes transcription elongation of immediate-early genes by releasing promoter-proximal pausing of RNA polymerase II |
| title_short | ERK-mediated NELF-A phosphorylation promotes transcription elongation of immediate-early genes by releasing promoter-proximal pausing of RNA polymerase II |
| title_sort | erk mediated nelf a phosphorylation promotes transcription elongation of immediate early genes by releasing promoter proximal pausing of rna polymerase ii |
| url | https://doi.org/10.1038/s41467-022-35230-4 |
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