<i>Inter-Ligand</i> STD NMR: An Efficient 1D NMR Approach to Probe Relative Orientation of Ligands in a Multi-Subsite Protein Binding Pocket

<i>Inter-Ligand</i> STD NMR: An Efficient 1D NMR Approach to Probe Relative Orientation of Ligands in a Multi-Subsite Protein Binding Pocket

In recent years, Saturation Transfer Difference NMR (STD NMR) has been proven to be a powerful and versatile ligand-based NMR technique to elucidate crucial aspects in the investigation of protein-ligand complexes. Novel STD NMR approaches relying on “multi-frequency” irradiation have enabled us to...

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Detaylı Bibliyografya
Asıl Yazarlar: Serena Monaco, Jonathan Ramírez-Cárdenas, Ana Teresa Carmona, Inmaculada Robina, Jesus Angulo
Materyal Türü: Makale
Dil:English
Baskı/Yayın Bilgisi: MDPI AG 2022-08-01
Seri Bilgileri:Pharmaceuticals
Konular:
saturation transfer difference NMR
multi-frequency STD NMR
multi-subsite binding pockets
protein-ligand interactions
ligand-based NMR
Fragment Based Drug Discovery
Online Erişim:https://www.mdpi.com/1424-8247/15/8/1030

Internet

https://www.mdpi.com/1424-8247/15/8/1030

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