Dysfunction in mitochondrial electron transport chain drives the pathogenesis of pulmonary arterial hypertension: insights from a multi-omics investigation

Dysfunction in mitochondrial electron transport chain drives the pathogenesis of pulmonary arterial hypertension: insights from a multi-omics investigation

Abstract Background Pulmonary arterial hypertension (PAH) is a progressive disorder that can lead to right ventricular failure and severe consequences. Despite extensive efforts, limited progress has been made in preventing the progression of PAH. Mitochondrial dysfunction is implicated in the devel...

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Bibliographic Details
Main Authors: Xin Zhang, Jieling Li, Minyi Fu, Xijie Geng, Junjie Hu, Ke-Jing Tang, Pan Chen, Jianyong Zou, Xiaoman Liu, Bo Zeng
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Respiratory Research
Subjects:
Pulmonary arterial hypertension
Mitochondrial dysfunction
Citric acid cycle
Transcriptomics
Metabolomics
Machine learning
Online Access:https://doi.org/10.1186/s12931-025-03099-8

Internet

https://doi.org/10.1186/s12931-025-03099-8

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