Biodistribution of a Radiolabeled Antibody in Mice as an Approach to Evaluating Antibody Pharmacokinetics

(1) Background: Monoclonal antibodies are used in the treatment of multiple conditions including cancer, autoimmune disorders, and infectious diseases. One of the initial steps in the selection of an antibody candidate for further pre-clinical development is determining its pharmacokinetics in small...

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Bibliographic Details
Main Authors: Kevin J. H. Allen, Rubin Jiao, Mackenzie E. Malo, Connor Frank, Ekaterina Dadachova
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Pharmaceutics
Subjects:
Online Access:https://www.mdpi.com/1999-4923/10/4/262