Specific miRNA Stabilization by Gld2-Catalyzed Monoadenylation

MicroRNAs (miRNAs) are small, noncoding RNAs that inhibit translation and promote mRNA decay. The levels of mature miRNAs are the result of different rates of transcription, processing, and turnover. The noncanonical polymerase Gld2 has been implicated in the stabilization of miR-122, possibly throu...

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Bibliographic Details
Main Authors: Andrea D’Ambrogio, Weifeng Gu, Tsuyoshi Udagawa, Craig C. Mello, Joel D. Richter
Format: Article
Language:English
Published: Elsevier 2012-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124712003786