Paraneoplastic Pemphigus Autoantibodies Against C-terminus of Desmoplakin Induced Acantholysis In Vitro and In Vivo

Paraneoplastic Pemphigus Autoantibodies Against C-terminus of Desmoplakin Induced Acantholysis In Vitro and In Vivo

Paraneoplastic pemphigus (PNP) is an autoimmune bullous disease associated with underlying neoplasms and characterized by antibodies against desmoglein 3 (Dsg 3) and plakins. Autoantibodies against desmoglein 3 in sera of patients with PNP have been proven to cause acantholysis in vivo in neonatal m...

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Bibliographic Details
Main Authors: Xue Wang, Rui Wang, Dingfang Bu, Leyi Wang, Yuexin Zhang, Yuan Chang, Chenyang Zhang, Xixue Chen, Xuejun Zhu, Zhi Liu, Mingyue Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
Paraneoplastic pemphigus
desmoplakin
plakin
desmoglein
acantholoysis
mouse model
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.886226/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.886226/full

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