Opposing Roles for the α Isoform of the Catalytic Subunit of Protein Phosphatase 1 in Inside–Out and Outside–In Integrin Signaling in Murine Platelets

Opposing Roles for the α Isoform of the Catalytic Subunit of Protein Phosphatase 1 in Inside–Out and Outside–In Integrin Signaling in Murine Platelets

Platelet activation during hemostasis and thrombosis is facilitated by agonist-induced inside–out and integrin α<sub>IIb</sub>β<sub>3</sub>-initiated outside–in signaling via protein kinases and phosphatases. Pharmacological inhibitor studies suggest that the serine/threonine...

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Bibliographic Details
Main Authors: Tanvir Khatlani, Subhashree Pradhan, Kimberly Langlois, Deepika Subramanyam, Rolando E. Rumbaut, K. Vinod Vijayan
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Cells
Subjects:
platelets
protein phosphatase 1 alpha
p38 mitogen-activated protein kinase
fibrinogen
Online Access:https://www.mdpi.com/2073-4409/12/20/2424

Internet

https://www.mdpi.com/2073-4409/12/20/2424

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