Mouse hepatic oval cells require Met-dependent PI3K to impair TGF-β-induced oxidative stress and apoptosis.

Mouse hepatic oval cells require Met-dependent PI3K to impair TGF-β-induced oxidative stress and apoptosis.

We have previously shown that oval cells harboring a genetically inactivated Met tyrosine kinase (Met(-/-) oval cells) are more sensitive to TGF-β-induced apoptosis than cells expressing a functional Met (Met(flx/flx)), demonstrating that the HGF/Met axis plays a pivotal role in oval cell survival....

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Bibliographic Details
Main Authors: Adoración Martínez-Palacián, Gaelle del Castillo, Amileth Suárez-Causado, María García-Álvaro, Diego de Morena-Frutos, Margarita Fernández, Cesáreo Roncero, Isabel Fabregat, Blanca Herrera, Aránzazu Sánchez
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3534654?pdf=render

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http://europepmc.org/articles/PMC3534654?pdf=render

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