Mitochondrial stress response gene Clpp deficiency impairs oocyte competence and deteriorate cyclophosphamide-induced ovarian damage in young mice

Mitochondrial stress response gene Clpp deficiency impairs oocyte competence and deteriorate cyclophosphamide-induced ovarian damage in young mice

Chemotherapy is extensively used to treat cancers and is often associated with ovarian damage and leads to premature ovarian insufficiency and infertility, while the role of mitochondria during ovarian damage with chemotherapy remains unknown. This study used a mouse model with oocyte-specific delet...

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Bibliographic Details
Main Authors: Guangxin Li, Jingkai Gu, Xiaomei Zhou, Ting Wu, Xian Li, Renwu Hua, Zhuo Hai, Yuan Xiao, Jiaping Su, Willian S. B. Yeung, Kui Liu, Chenxi Guo, Tianren Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Endocrinology
Subjects:
oocyte
follicle development
cyclophosphamide
mitochondria
ClpP
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2023.1122012/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2023.1122012/full

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