Monastrol disrupts KIFC1-ATP dynamics: Towards newer anticancer mechanism

Monastrol disrupts KIFC1-ATP dynamics: Towards newer anticancer mechanism

Mitotic kinesins are eukaryotic proteins that play a vital role in cellular mitosis. Their over-expression in malignant rather than normal cells and their specific cellular role made kinesin inhibitors a promising cancer therapeutics. The realization of in-vitro antitumor activity of the investigati...

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Bibliographic Details
Main Authors: Musab Ali, Ali H. Rabbad, Mahmoud E. Soliman
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Chemical Physics Impact
Subjects:
Kinesin inhibitors
Kinesin-like protein
Monastrol
Molecular dynamic simulation
Binding free energy
Anticancer agents
Online Access:http://www.sciencedirect.com/science/article/pii/S2667022424000240

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http://www.sciencedirect.com/science/article/pii/S2667022424000240

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