RGS11-CaMKII complex mediated redox control attenuates chemotherapy-induced cardiac fibrosis

RGS11-CaMKII complex mediated redox control attenuates chemotherapy-induced cardiac fibrosis

Dose limiting cardiotoxicity remains a major limiting factor in the clinical use of several cancer chemotherapeutics including anthracyclines and the antimetabolite 5-fluorouracil (5-FU). Prior work has demonstrated that chemotherapeutics increase expression of R7 family regulator of G protein signa...

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Bibliographic Details
Main Authors: Kiran Das, Madhuri Basak, Tarun Mahata, Manish Kumar, Dinesh Kumar, Sayan Biswas, Suvro Chatterjee, Mahammed Moniruzzaman, Nimai Chandra Saha, Kausik Mondal, Pranesh Kumar, Priyadip Das, Adele Stewart, Biswanath Maity
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Redox Biology
Subjects:
RGS proteins
Chemotherapy
Cardiotoxicity
Oxidative stress
Cell death
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722002592

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http://www.sciencedirect.com/science/article/pii/S2213231722002592

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