PARP1 Might Substitute HSF1 to Reactivate Latent HIV-1 by Binding to Heat Shock Element

PARP1 Might Substitute HSF1 to Reactivate Latent HIV-1 by Binding to Heat Shock Element

At present, the barrier to HIV-1 functional cure is the persistence of HIV-1 reservoirs. The “shock (reversing latency) and kill (antiretroviral therapy)” strategy sheds light on reducing or eliminating the latent reservoir of HIV-1. However, the current limits of latency-reversing agents (LRAs) are...

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Bibliographic Details
Main Authors: Xinfeng Xu, Yingtong Lin, Xiaoyun Zeng, Chan Yang, Siqin Duan, Liqiong Ding, Wanzhen Lu, Jian Lin, Xiaoyan Pan, Xiancai Ma, Shuwen Liu
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cells
Subjects:
HIV-1 latency
latency reversing agents
heat shock factor 1
heat shock element
functional cure
PARP1
Online Access:https://www.mdpi.com/2073-4409/11/15/2331

Internet

https://www.mdpi.com/2073-4409/11/15/2331

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