Dietary Pyridoxine Controls Efficacy of Vitamin B<sub>6</sub>-Auxotrophic Tuberculosis Vaccine Bacillus Calmette-Guérin Δ<italic toggle="yes">ureC</italic>::<italic toggle="yes">hly</italic> Δ<italic toggle="yes">pdx1</italic> in Mice
ABSTRACT The only tuberculosis (TB) vaccine in use today, bacillus Calmette-Guérin (BCG), provides insufficient protection and can cause adverse events in immunocompromised individuals, such as BCGosis in HIV+ newborns. We previously reported improved preclinical efficacy and safety of the recombina...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
American Society for Microbiology
2014-07-01
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| Series: | mBio |
| Online Access: | https://journals.asm.org/doi/10.1128/mBio.01262-14 |