A novel monoclonal IgG1 antibody specific for Galactose-alpha-1,3-galactose questions alpha-Gal epitope expression by bacteria

A novel monoclonal IgG1 antibody specific for Galactose-alpha-1,3-galactose questions alpha-Gal epitope expression by bacteria

The alpha-Gal epitope (α-Gal) with the determining element galactose-α1,3-galactose can lead to clinically relevant allergic reactions and rejections in xenotransplantation. These immune reactions can develop because humans are devoid of this carbohydrate due to evolutionary loss of the enzyme α1,3-...

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Bibliographic Details
Main Authors: Luisa Kreft, Aloys Schepers, Miriam Hils, Kyra Swiontek, Andrew Flatley, Robert Janowski, Mohammadali Khan Mirzaei, Michael Dittmar, Neera Chakrapani, Mahesh S. Desai, Stefanie Eyerich, Li Deng, Dierk Niessing, Konrad Fischer, Regina Feederle, Simon Blank, Carsten B. Schmidt-Weber, Christiane Hilger, Tilo Biedermann, Caspar Ohnmacht
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
alpha-Gal
α-Gal
IgG
monoclonal antibody
carbohydrate
red meat allergy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.958952/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.958952/full

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