Monocyte Transcriptional Responses to Mycobacterium tuberculosis Associate with Resistance to Tuberculin Skin Test and Interferon Gamma Release Assay Conversion

Monocyte Transcriptional Responses to Mycobacterium tuberculosis Associate with Resistance to Tuberculin Skin Test and Interferon Gamma Release Assay Conversion

ABSTRACT Heavy exposure to Mycobacterium tuberculosis, the etiologic agent of tuberculosis (TB) and among the top infectious killers worldwide, results in infection that is cleared, contained, or progresses to disease. Some heavily exposed tuberculosis contacts show no evidence of infection using th...

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Bibliographic Details
Main Authors: Jason D. Simmons, Kimberly A. Dill-McFarland, Catherine M. Stein, Phu T. Van, Violet Chihota, Thobani Ntshiqa, Pholo Maenetje, Glenna J. Peterson, Penelope Benchek, Mary Nsereko, Kavindhran Velen, Katherine L. Fielding, Alison D. Grant, Raphael Gottardo, Harriet Mayanja-Kizza, Robert S. Wallis, Gavin Churchyard, W. Henry Boom, Thomas R. Hawn
Format: Article
Language:English
Published: American Society for Microbiology 2022-06-01
Series:mSphere
Subjects:
tumor necrosis factor alpha
innate immunity
sequence analysis
RNA
transcriptome
host-pathogen interactions
Online Access:https://journals.asm.org/doi/10.1128/msphere.00159-22

Internet

https://journals.asm.org/doi/10.1128/msphere.00159-22

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