Development and use of a high-throughput screen to identify novel modulators of the corticotropin releasing factor binding protein

Development and use of a high-throughput screen to identify novel modulators of the corticotropin releasing factor binding protein

Background: Stress responses are believed to involve corticotropin releasing factor (CRF), its two cognate receptors (CRF1 and CRF2), and the CRF-binding protein (CRFBP). Whereas decades of research has focused on CRF1, the role of CRF2 in the central nervous system (CNS) has not been thoroughly inv...

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Bibliographic Details
Main Authors: Carolina L. Haass-Koffler, T. Chase Francis, Pauravi Gandhi, Reesha Patel, Mohammad Naemuddin, Carsten K. Nielsen, Selena E. Bartlett, Antonello Bonci, Stefan Vasile, Becky L. Hood, Eigo Suyama, Michael P. Hedrick, Layton H. Smith, Allison S. Limpert, Marisa Roberto, Nicholas D.P. Cosford, Douglas J. Sheffler
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:SLAS Discovery
Subjects:
Stress
CRF2
CRFBP
NAM
HTS
AUD
Online Access:http://www.sciencedirect.com/science/article/pii/S247255522213697X

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